Table of Contents
May 9, 2002
Volume 45, Issue 10
Pages 5-2122
Perspective Series
p 5Publication Date (Web): May 02, 2002 (Editorial)
DOI: 10.1021/jm020137v
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Letters
Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
Richard L. Jarvest, John M. Berge, Valerie Berry, Helen F. Boyd, Murray J. Brown, John S. Elder, Andrew K. Forrest, Andrew P. Fosberry, Daniel R. Gentry, Martin J. Hibbs, Deborah D. Jaworski, Peter J. O'Hanlon, Andrew J. Pope, Stephen Rittenhouse, Robert J. Sheppard, Courtney Slater-Radosti, and Angela Worby
pp 1959–1962Publication Date (Web): April 09, 2002 (Letter)
DOI: 10.1021/jm025502x
Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines
Jon L. Collins, Adam M. Fivush, Michael A. Watson, Cristin M. Galardi, Michael C. Lewis, Linda B. Moore, Derek J. Parks, Joan G. Wilson, Tim K. Tippin, Jane G. Binz, Kelli D. Plunket, Daniel G. Morgan, Elizabeth J. Beaudet, Karl D. Whitney, Steven A. Kliewer, and Timothy M. Willson
pp 1963–1966Publication Date (Web): April 17, 2002 (Letter)
DOI: 10.1021/jm0255116
Docking into Knowledge-Based Potential Fields: A Comparative Evaluation of DrugScore
Christoph A. Sotriffer, Holger Gohlke, and Gerhard Klebe
pp 1967–1970Publication Date (Web): April 20, 2002 (Letter)
DOI: 10.1021/jm025507u
Articles
Solid-Phase Library Synthesis, Screening, and Selection of Tight-Binding Reduced Peptide Bond Inhibitors of a Recombinant Leishmania mexicana Cysteine Protease B
Phaedria M. St. Hilaire, Lira C. Alves, Fatima Herrera, Manat Renil, Sanya J. Sanderson, Jeremy C. Mottram, Graham H. Coombs, Maria A. Juliano, Luiz Juliano, Jorge Arevalo, and Morten Meldal
pp 1971–1982Publication Date (Web): April 03, 2002 (Article)
DOI: 10.1021/jm0110901
Development of a Combined Protein and Pharmacophore Model for Cytochrome P450 2C9
Marcel J. de Groot, Alexander A. Alex, and Barry C. Jones
pp 1983–1993Publication Date (Web): April 06, 2002 (Article)
DOI: 10.1021/jm0110791
Distribution of Furamidine Analogues in Tumor Cells: Influence of the Number of Positive Charges
Amélie Lansiaux, Laurent Dassonneville, Michaël Facompré, Arvind Kumar, Chad E. Stephens, Miroslav Bajic, Farial Tanious, W. David Wilson, David W. Boykin, and Christian Bailly
pp 1994–2002Publication Date (Web): April 05, 2002 (Article)
DOI: 10.1021/jm010539n
Synthesis, In Vitro Receptor Binding, and In Vivo Evaluation of Fluorescein and Carbocyanine Peptide-Based Optical Contrast Agents
Samuel Achilefu, Hermo N. Jimenez, Richard B. Dorshow, Joseph E. Bugaj, Elizabeth G. Webb, R. Randy Wilhelm, Raghavan Rajagopalan, Jill Johler, and Jack L. Erion
pp 2003–2015Publication Date (Web): April 10, 2002 (Article)
DOI: 10.1021/jm010519l
Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease
Theodore O. Johnson, Ye Hua, Hiep T. Luu, Edward L. Brown, Fora Chan, Shao Song Chu, Peter S. Dragovich, Brian W. Eastman, Rose Ann Ferre, Shella A. Fuhrman, Thomas F. Hendrickson, Fausto C. Maldonado, David A. Matthews, James W. Meador, III, Amy K. Patick, Siegfried H. Reich, Donald J. Skalitzky, Stephen T. Worland, Michelle Yang, and Leora S. Zalman
pp 2016–2023Publication Date (Web): April 12, 2002 (Article)
DOI: 10.1021/jm010435c
C-Terminal Cyclization of an SDF-1 Small Peptide Analogue Dramatically Increases Receptor Affinity and Activation of the CXCR4 Receptor
Christopher Tudan, Gordon E. Willick, Sarabjit Chahal, Lakhdar Arab, Ping Law, Hassan Salari, and Ahmed Merzouk
pp 2024–2031Publication Date (Web): April 17, 2002 (Article)
DOI: 10.1021/jm0104015
Design and Synthesis of Novel 5-Substituted Acyclic Pyrimidine Nucleosides as Potent and Selective Inhibitors of Hepatitis B Virus
Rakesh Kumar, Mahendra Nath, and D. Lorne J. Tyrrell
pp 2032–2040Publication Date (Web): April 09, 2002 (Article)
DOI: 10.1021/jm010410d
Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ETA Antagonism
Natsuki Ishizuka, Ken-ichi Matsumura, Katsunori Sakai, Masafumi Fujimoto, Shin-ichi Mihara, and Teruo Yamamori
pp 2041–2055Publication Date (Web): April 09, 2002 (Article)
DOI: 10.1021/jm010382z
Synthesis and Biological Evaluation of New Citrate-Based Siderophores as Potential Probes for the Mechanism of Iron Uptake in Mycobacteria
Hongyan Guo, Saleh A. Naser, George Ghobrial, and Otto Phanstiel IV
pp 2056–2063Publication Date (Web): April 04, 2002 (Article)
DOI: 10.1021/jm0104522
Hematoporphyrin-Derived Soluble Porphyrin−Platinum Conjugates with Combined Cytotoxic and Phototoxic Antitumor Activity
Christian Lottner, Karl-Christian Bart, Günther Bernhardt, and Henri Brunner
pp 2064–2078Publication Date (Web): April 17, 2002 (Article)
DOI: 10.1021/jm0110688
Soluble Tetraarylporphyrin−Platinum Conjugates as Cytotoxic and Phototoxic Antitumor Agents
Christian Lottner, Karl-Christian Bart, Günther Bernhardt, and Henri Brunner
pp 2079–2089Publication Date (Web): April 17, 2002 (Article)
DOI: 10.1021/jm0110690
Adenine Nucleotide Analogues Locked in a Northern Methanocarba Conformation: Enhanced Stability and Potency as P2Y1 Receptor Agonists
R. Gnana Ravi, Hak Sung Kim, Jörg Servos, Herbert Zimmermann, Kyeong Lee, Savitri Maddileti, José L. Boyer, T. Kendall Harden, and Kenneth A. Jacobson
pp 2090–2100Publication Date (Web): April 12, 2002 (Article)
DOI: 10.1021/jm010538v
Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors
Timothy A. Shepherd, James A. Aikins, David Bleakman, Buddy E. Cantrell, John P. Rearick, Richard L. Simon, Edward C. R. Smith, Gregory A. Stephenson, and Dennis M. ZimmermanAllan Mandelzys, Keith R. Jarvie, Ken Ho, Michelle Deverill, and Rajender K. Kamboj
pp 2101–2111Publication Date (Web): April 17, 2002 (Article)
DOI: 10.1021/jm0105474
Brief Articles
A Trypanocidal Phenazine Derived from β-Lapachone
Cleverson Neves-Pinto, Valéria R. S. Malta, Maria do Carmo F. R. Pinto, Regina H. A. Santos, Solange L. de Castro, and Antônio Ventura Pinto
pp 2112–2115Publication Date (Web): March 26, 2002 (Brief Article)
DOI: 10.1021/jm010377v
Synthesis and in Vitro Evaluation of Quaternary Ammonium Derivatives of Chlorambucil and Melphalan, Anticancer Drugs Designed for the Chemotherapy of Chondrosarcoma
Isabelle Giraud, Maryse Rapp, Jean-Claude Maurizis, and Jean-Claude Madelmont
pp 2116–2119Publication Date (Web): April 05, 2002 (Brief Article)
DOI: 10.1021/jm010926x
Book Reviews
Medicinal Natural Products. A Biosynthetic Approach. 2nd Edition By Paul M. Dewick. John Wiley & Sons, New York. 2002. xii + 507 pp. 19 × 25.5 cm. ISBN 0-471-49640-5. $115.00.
Robert J. Krueger
p 2120Publication Date (Web): April 10, 2002 (Book Review)
DOI: 10.1021/jm020128m
Reviews in Computational Chemistry. Volume 17 Edited by Kenny B. Lipkowitz and Donald B. Boyd. Wiley-VCH, New York. 2001. xxxv + 399 pp. 16 × 24.5 cm. ISBN 0-471-39845-4. $150.00.
Hugo O. Villar
pp 2120–2121Publication Date (Web): April 11, 2002 (Book Review)
DOI: 10.1021/jm020129e
Additions and Corrections
Physicochemical Determinants of Passive Membrane Permeability: Role of Solute Hydrogen-Bonding Potential and Volume.
Jay T. Goodwin, Robert A. Conradi, Norman F. H. Ho, and Philip S. Burton:
p 2122Publication Date (Web): April 10, 2002 (Addition/Correction)
DOI: 10.1021/jm0200963